Topical oil emulsion dressing12/9/2023 ![]() However, not only the drug but also the ointment base plays an important role in the treatment with ointments and other topical agents, and the choice of ointment base is important for effective topical therapy of skin wounds. Research on developing topical therapies for the treatment of wound-healing deficits using ointments and dressings containing effective drugs is ongoing to improve the prolongation and interruption of these processes. As a result, delayed re-epithelialization of wounds and impaired migration and proliferation of keratinocytes and fibroblasts result in the formation of chronic wounds. 3, 4) Complex multiple factors, including a reduction in the level of substance P, 5) decreased endothelial nitric oxide synthase activity, 6) increased expression of caspase, 7) decreased vasculogenesis, 8) reduction in the chemotactic and phagocytic activities of neutrophils, 9) and prolongation and interruption of the collagen synthesis reaction, 10) cause an inflammatory response and cellular proliferation during the skin wound healing process. 2) Wound-healing deficits of the skin, one of the most common complications of diabetes, have a long-term impact on the patient’s QOL. 1, 2) The chronic hyperglycemia of diabetes mellitus is followed by damage and dysfunction of the eyes, kidneys, nerves, and blood vessels. These findings provide information for the selection of ointment bases useful for application to skin wounds in patients with diabetes.ĭiabetes mellitus is a metabolic disease characterized by hyperglycemia and hypoinsulinemia. In conclusion, skin wound healing in STZ rats is affected by the properties of the ointment base, and it is important to use an ointment base that controls the drying of the wound area in STZ rats. The therapeutic effect of both white ointment and absorbent cream was higher in the STZ rats group than that in the non-treated group, and delayed wound healing was observed in STZ rats treated with macrogol ointment. Each of the three ointment bases was applied to the skin wound area in normal rats, and there was no difference in the therapeutic effect. Skin wound healing in STZ rats was delayed compared with that in normal rats. Three ointment bases were used: white ointment (oil-based), absorbent cream (emulsion-based, w/o), and macrogol ointment (water-based). In this study, we investigated the effect of various ointment bases on skin wound healing in normal and streptozotocin-induced diabetic rats (STZ rats). Therefore, the topical treatment of wound areas with drug-containing ointments and dressings is important. ![]() Wound-healing deficits of the skin, one of the most common complications in patients with diabetes, delay wound healing, significantly reducing the patient’s QOL. ![]()
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